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Visium Spatial Transcriptomics

The Visium Spatial Transcriptomics system from 10x Genomics captures RNA from frozen or FFPE tissue sections to create a high resolution RNA-seq map.  The grid of 5000 uniquely-barcoded oligonucleotide spots captures and tags mRNAs, permitting determination of the specific transcriptome of each spot.  Expression profiles can then be compared and mapped back to the tissue morphology by overlay on a standard H&E stained or immunofluorescence image of the tissue slice. 

Gif of clustering overlay on stained tissue

The Arts & Sciences Imaging Center is a participant in the 10x Genomics Visium Enablement Program, which verifies 10x Genomics authorized reagents and methods for spatial transcriptomics.  Contact us to learn more or to discuss your project.


(Images shared with permission of Lance Johnson and Josh Morganti)